期刊
NATURE COMMUNICATIONS
卷 8, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/ncomms15095
关键词
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资金
- Lustgarten Foundation
- NCI [P01 CA117969]
- Cancer Prevention and Research Institute of Texas
- UT MDACC Khalifa Bin Zayed Al Nahya Foundation
- NCI Cancer Center [NCI P30 CA016672]
- CPRIT [RP110532]
- American Cancer Society [RSG-16-005-01]
- Center for Radiation Oncology Research
- NIH NCI [CA196403]
- University of Texas MD Anderson Cancer Center
- Career Development Award from the Brain Tumor SPORE [P50CA127001-07]
- NVidia
- NIH through MDACC [CA016672]
The exact nature and dynamics of pancreatic ductal adenocarcinoma (PDAC) immune composition remains largely unknown. Desmoplasia is suggested to polarize PDAC immunity. Therefore, a comprehensive evaluation of the composition and distribution of desmoplastic elements and T-cell infiltration is necessary to delineate their roles. Here we develop a novel computational imaging technology for the simultaneous evaluation of eight distinct markers, allowing for spatial analysis of distinct populations within the same section. We report a heterogeneous population of infiltrating T lymphocytes. Spatial distribution of cytotoxic Tcells in proximity to cancer cells correlates with increased overall patient survival. Collagen-I and alpha SMA(+) fibroblasts do not correlate with paucity in T-cell accumulation, suggesting that PDAC desmoplasia may not be a simple physical barrier. Further exploration of this technology may improve our understanding of how specific stromal composition could impact T-cell activity, with potential impact on the optimization of immune-modulatory therapies.
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