期刊
NATURE COMMUNICATIONS
卷 8, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-017-00737-8
关键词
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资金
- University of Texas Medical Branch (UTMB)
- University of Texas STARs Award
- CDC grant for the Western Gulf Center of Excellence for Vector-Borne Diseases
- Pan American Health Organization [SCON2016-01353]
- Kleberg Foundation
- UTMB CTSA [UL1TR-001439]
- NIH [AI127744, AI120942, AI073755, AI104972, AI106695]
- National Institute of Allergy and Infectious Diseases
- CAPES (Zika Fast-Track)
- CNPq from Ministry of Science and Technology of Brazil [440405/2016-5, 303999/2016-0]
- Ministry of Health
Zika virus infection during pregnancy can cause congenital abnormities or fetal demise. The persistence of Zika virus in the male reproductive system poses a risk of sexual transmission. Here we demonstrate that live-attenuated Zika virus vaccine candidates containing deletions in the 3' untranslated region of the Zika virus genome (ZIKV-3'UTR-LAV) prevent viral transmission during pregnancy and testis damage in mice, as well as infection of nonhuman primates. After a single-dose vaccination, pregnant mice challenged with Zika virus at embryonic day 6 and evaluated at embryonic day 13 show markedly diminished levels of viral RNA in maternal, placental, and fetal tissues. Vaccinated male mice challenged with Zika virus were protected against testis infection, injury, and oligospermia. A single immunization of rhesus macaques elicited a rapid and robust antibody response, conferring complete protection upon challenge. Furthermore, the ZIKV-3'UTR-LAV vaccine candidates have a desirable safety profile. These results suggest that further development of ZIKV-3'UTR-LAV is warranted for humans.
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