期刊
CELLULAR IMMUNOLOGY
卷 318, 期 -, 页码 49-54出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2017.06.003
关键词
Middle cerebral artery occlusion; Sex-specific; Lymphocyte; Regulatory B cells; Anti-inflammatory macrophages; Regulatory T cells
资金
- NIH/National Institute of Neurological Disorders and Stroke [1RO1 NS075887, 1RO1 NS076013]
- American Heart Association [17GRNT33220001]
Stroke is the leading cause of disability in the United States. Sex differences, including smaller infarcts in females and greater involvement of immune-mediated inflammation in males may affect the efficacy of immune-modulating interventions. To address these differences, we sought to identify distinct stroke-modifying mechanisms in female vs. male mice. The current study demonstrated smaller infarcts and increased levels of regulatory CD19(+) CD5(+) CD1d(hi) B10 cells as well as anti-inflammatory CD11b(+) CD206(+) microglia/ macrophages in the ipsilateral vs. contralateral hemisphere of female but not male mice undergoing 60 min middle cerebral artery occlusion followed by 96 h of reperfusion. Moreover, female mice with MCAO had increased total spleen cell numbers but lower B10 levels in spleens. These results elucidate differing sex-dependent regulatory mechanisms that account for diminished stroke severity in females and underscore the need to test immune-modulating therapies for stroke in both males and females.
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