期刊
NATURE COMMUNICATIONS
卷 8, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/ncomms14517
关键词
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资金
- National Institutes of Health [CA16058, CA168505]
- University of Texas MD Anderson Cancer Center
- American Thyroid Association
- National Institutes of Health (NIH) [U01 DE019765-01]
- Cancer Center Support Grant [CA016672]
- Netherlands Organization for Scientific Research [184021007]
- Common Fund of the Office of the Director of the National Institutes of Health
- NCI
- NHGRI
- NHLBI
- NIDA
- NIMH
- NINDS
- NCI\SAIC-Frederick, Inc. (SAIC-F) [10XS170, 10XS171, X10S172]
- Laboratory, Data Analysis and Coordinating Center (LDACC) [HHSN268201000029C]
- SAIC-F [10ST1035, HHSN261200800001E]
- University of Geneva [MH090941, MH101814]
- University of Chicago [MH090951, MH090937, MH101820, MH101825]
- University of North Carolina-Chapel Hill [MH090936, MH101819]
- Harvard University [MH090948]
- Stanford University [MH101782]
- Washington University St Louis [MH101810]
- University of Pennsylvania [MH101822]
- [DA006227]
- [DA033684]
- [N01MH000028]
The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European descent. Our results yield five novel loci (all with P-combined <3 x 10(-8)): 1q42.2 (rs12129938 in PCNXL2), 3q26.2 (rs6793295 a missense mutation in LRCC34 near TERC), 5q22.1 (rs73227498 between NREP and EPB41L4A), 10q24.33 (rs7902587 near OBFC1), and two independently associated variants at 15q22.33 (rs2289261 and rs56062135; both in SMAD3). We also confirm recently published association results from a Chinese study of a variant on 5p15.33 (rs2736100 near the TERT gene) and present a stronger association result for a moderately correlated variant (rs10069690; OR = 1.20, P = 3.2 x 10(-7)) based on our study of individuals of European ancestry. In combination, these results raise several opportunities for future studies of the pathogenesis of thyroid cancer.
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