期刊
NATURE COMMUNICATIONS
卷 8, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-017-01906-5
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资金
- Ministry of Science and Technology, Taiwan
Singlet O-2 is a key reactive oxygen species responsible for photodynamic therapy and is generally recognized to be chemically reactive towards C=C double bonds. Herein, we report the hydroperoxidation/lactonization of alpha-ethereal C-H bonds by singlet O-2 ((1)Delta(g)) under exceptionally mild conditions, i.e., room temperature and ambient pressure, with modest to high yields (38 similar to 90%) and excellent site selectivity. Singlet O-2 has been known for > 90 years, but was never reported to be able to react with weakly activated C-H bonds in saturated hydrocarbons. Theoretical calculations indicate that singlet O-2 directly inserts into the alpha-ethereal C-H bond in one step with conservation of steric configuration in products. The current discovery of chemical reaction of singlet oxygen with weakly activated solvent C-H bonds, in addition to physical relaxation pathway, provides an important clue to a 35-year-old unresolved mystery regarding huge variations of solvent dependent lifetime of singlet O-2.
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