期刊
NATURE COMMUNICATIONS
卷 8, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms15594
关键词
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资金
- National Heart Lung and Blood Institute of the National Institutes of Health as a Program of Excellence in Nanotechnology Award [HHSN268201000043C]
- Cancer Prevention and Research Institute of Texas [RR140081]
- NIH R01 [R01HL121264]
- NIH U54 [HL112309]
- NSF CAREER [1150235]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1150235] Funding Source: National Science Foundation
The vascular endothelium presents a major transport barrier to drug delivery by only allowing selective extravasation of solutes and small molecules. Therefore, enhancing drug transport across the endothelial barrier has to rely on leaky vessels arising from disease states such as pathological angiogenesis and inflammatory response. Here we show that the permeability of vascular endothelium can be increased using an external magnetic field to temporarily disrupt endothelial adherens junctions through internalized iron oxide nanoparticles, activating the paracellular transport pathway and facilitating the local extravasation of circulating substances. This approach provides a physically controlled drug delivery method harnessing the biology of endothelial adherens junction and opens a new avenue for drug delivery in a broad range of biomedical research and therapeutic applications.
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