期刊
BIOMATERIALS
卷 141, 期 -, 页码 296-313出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2017.07.005
关键词
Selenium nanoparticles; Ruthenium complexes; Antibacterial peptide; Selective imaging; Theranostic
资金
- National Natural Science Foundation of China [21171070, 21371075]
- Natural Science Foundation of Guangdong Province [2014A030311025]
- Planned Item of Science and Technology of Guangdong Province [2016A020217011]
Bacterial infection has been a threat to human health, and so early diagnosis and treatment of bacterial infection is an urgent problem that needs to be solved. In this work, a multifunctional theranostic selenium nanoplatform (Se@PEP-Ru NPs) with early imaging diagnosis and efficient treatment of bacterial infections was designed and constructed. First, the antibacterial peptide UB129-41 (PEP) was linked to functionalized Selenium nanoparticles (NPs), which enhanced the stability of the antimicrobial peptide and also caused the nanocomposites to specifically target bacterial infection. Ruthenium complexes with good antibacterial activity and fluorescence properties were then coated on to their outer layers. It was worth mentioning that, when the resulting nanoprobe was injected into mice by intravenous injection it was found to be sensitive to sites of bacterial infection for selective fluorescence imaging and targeted therapy. Thus, it can be used to distinguish between bacterial infection, inflammation, and tumor induced tissue infection with high specificity. In the further antibacterial activity experiments, Ruthenium complexes showed synergistic antimicrobial activity with Se NPs, which indicated that the antibacterial activity of Se@PEP-Ru NPs was the strongest that could promote wound healing. Thus, Se@PEPRu NPs appears to be a promising antimicrobial with good biocompatibility, excellent selectivity, and potent antimicrobial activity. (C) 2017 Elsevier Ltd. All rights reserved.
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