期刊
NATURE COMMUNICATIONS
卷 8, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms15253
关键词
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资金
- European Research Council (ERC)
- Swedish Research Council
- Novo Nordisk Foundation (including Tripartite Immunometabolism Consortium (TrIC) [NNF15CC0018486]
- CIMED
- Swedish Diabetes Foundation
- Stockholm Community
- Karolinska Institutet
- Erling-Persson Family Foundation
- KI-AZ ICMC
- Vallee Foundation
- Diabetes Research Program at Karolinska Institutet
- Novo Nordisk Fonden [NNF15OC0015894, NNF12OC1016064, NNF15SA0018486, NNF15SA0018346, NNF14OC0010187] Funding Source: researchfish
Differences in white adipose tissue (WAT) lipid turnover between the visceral (vWAT) and subcutaneous (sWAT) depots may cause metabolic complications in obesity. Here we compare triglyceride age and, thereby, triglyceride turnover in vWAT and sWAT biopsies from 346 individuals and find that subcutaneous triglyceride age and storage capacity are increased in overweight or obese individuals. Visceral triglyceride age is only increased in excessively obese individuals and associated with a lower lipid removal capacity. Thus, although triglyceride storage capacity in sWAT is higher than in vWAT, the former plateaus at substantially lower levels of excess WAT mass than vWAT. In individuals with central or visceral obesity, lipid turnover is selectively increased in vWAT. Obese individuals classified as 'metabolically unhealthy' (according to ATPIII criteria) who have small subcutaneous adipocytes exhibit reduced triglyceride turnover. We conclude that excess WAT results in depot-specific differences in lipid turnover and increased turnover in vWAT and/or decreased turnover in sWAT may result in metabolic complications of overweight or obesity.
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