期刊
NATURE COMMUNICATIONS
卷 8, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-017-02475-3
关键词
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资金
- UK's Department for Business, Energy and Industrial Strategy
- European Metrology Research Programme (EMRP) projects
- EMRP within EURAMET
- EMRP within European Union
- BBSRC [BB/M503113/1]
- BBSRC [BB/J006254/1, BB/N015487/1] Funding Source: UKRI
- EPSRC [EP/M028100/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [1493344, BB/N015487/1, BB/J006254/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [1351868, EP/M028100/1] Funding Source: researchfish
The spread of bacterial resistance to antibiotics poses the need for antimicrobial discovery. With traditional search paradigms being exhausted, approaches that are altogether different from antibiotics may offer promising and creative solutions. Here, we introduce a de novo peptide topology that-by emulating the virus architecture-assembles into discrete antimicrobial capsids. Using the combination of high-resolution and real-time imaging, we demonstrate that these artificial capsids assemble as 20-nm hollow shells that attack bacterial membranes and upon landing on phospholipid bilayers instantaneously (seconds) convert into rapidly expanding pores causing membrane lysis (minutes). The designed capsids show broad antimicrobial activities, thus executing one primary function-they destroy bacteria on contact.
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