期刊
DEVELOPMENT
卷 144, 期 16, 页码 2862-2872出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.153163
关键词
WT1; Developmental disorders; Homeostasis; Molecular mechanisms of disease
资金
- Medical Research Council (MRC)
- MRC [MR/N020405/1]
- MRC [MR/N020405/1] Funding Source: UKRI
- Medical Research Council [MR/N020405/1] Funding Source: researchfish
The study of genes mutated in human disease often leads to new insights into biology as well as disease mechanisms. One such gene is Wilms' tumour 1 (WT1), which plays multiple roles in development, tissue homeostasis and disease. In this Primer, I summarise how this multifaceted gene functions in various mammalian tissues and organs, including the kidney, gonads, heart and nervous system. This is followed by a discussion of our current understanding of the molecular mechanisms by which WT1 and its two major isoforms regulate these processes at the transcriptional and post-transcriptional levels.
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