期刊
NATURE COMMUNICATIONS
卷 8, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms14908
关键词
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资金
- National Natural Science Foundation of China [31400942, 81601969, 31571091]
- National Program on Key Basic Research Project of China (973 Program) [2014CB542205]
- Guangdong Natural Science Foundation [2014A030313387, S2013040014831]
- funds of Leading Talents of Guangdong
- Programme of Introducing Talents of Discipline to Universities [B14036]
- National Basic Research program [2015CB351800]
- Fundamental Research Funds for the Central Universities Grant [21609101]
- USA National Institutes of Health [R01 NS077003]
Animals promote their survival by avoiding rapidly approaching objects that indicate threats. In mice, looming-evoked defensive responses are triggered by the superior colliculus (SC) which receives direct retinal inputs. However, the specific neural circuits that begin in the retina and mediate this important behaviour remain unclear. Here we identify a subset of retinal ganglion cells (RGCs) that controls mouse looming-evoked defensive responses through axonal collaterals to the dorsal raphe nucleus (DRN) and SC. Looming signals transmitted by DRN-projecting RGCs activate DRN GABAergic neurons that in turn inhibit serotoninergic neurons. Moreover, activation of DRN serotoninergic neurons reduces looming-evoked defensive behaviours. Thus, a dedicated population of RGCs signals rapidly approaching visual threats and their input to the DRN controls a serotonergic self-gating mechanism that regulates innate defensive responses. Our study provides new insights into how the DRN and SC work in concert to extract and translate visual threats into defensive behavioural responses.
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