期刊
BIOSENSORS & BIOELECTRONICS
卷 94, 期 -, 页码 575-583出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2017.03.050
关键词
Iridum(III) complex; Endogenous sulfide production; Sulfide detection in living organism
类别
资金
- National Natural Science Foundation of China [21502075, 21575121]
- Hong Kong Baptist University [FRG2/16-17/007]
- Health and Medical Research Fund [HMRF/14-15/02CHEM]
- Research Grants Council [HKBU12301115]
- State Key Laboratory of Environmental and Biological Analysis Research Grant [SKLP-14-15-P001]
- Science and Technology Development Fund, Macao SAR [098/2014/A2]
- University of Macau [MYRG2015-00137-ICMS-QRCM, MYRG2016-00151-ICMS-QRCM, MRG044/LCH/2015/ICMS]
In this work, we report a novel iridium(III)-based luminescent switch on-off-on probe, for the in vitro and in vivo detection of sulfide ion. The mechanism of this platform is based on the effective charge transfer quenching of the iridium(III) complex 1 by Fe3+, followed by the restoration of luminescence upon the addition of Na2S. The probe, hereinafter referred to as 1 Fe3+, exhibited a linear range of detection for Na2S from 0.01 to 1.5 mM, with a detection limit of 2.9 1.1M at signal-to-noise ratio (S/N) of 3. We also demonstrate the utility of 1 Fe3+ for cell-based imaging as well as for the detection of enzymatic sulfide generation in living zebrafish.
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