期刊
NATURE COMMUNICATIONS
卷 8, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms15096
关键词
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资金
- Israel Science Foundation [347/15]
- Legacy Heritage Biomedical Program of the Israel Science Foundation [322/13]
- Dr Beth Rom-Rymer Stem Cell Research Fund
- Nella and Leon Benoziyo Center for Neurological Diseases
- Yeda-Sela Center for Basic Research
- Jeanne and Joseph Nissim Foundation for Life Sciences Research
- Wohl Biology Endowment Fund
- Fritz Thyssen Stiftung
- Lulu P. & David J. Levidow Fund for Alzheimer's Diseases and Neuroscience Research
- Helen and Martin Kimmel Stem Cell Research Institute
- David and Fela Shapell Family Center for Genetic Disorders Research
- National Health and Medical Research Council Career Development Fellowship [APP1105420]
In recent years the notion that malfunctioning of the immune system may result in developmental brain diseases has emerged. However, the role of immune molecules in the developing brain has not been well explored. The complement pathway converges to cleave C3. Here we show that key proteins in the lectin arm of this pathway, MASP1, MASP2 and C3, are expressed in the developing cortex and that neuronal migration is impaired in knockout and knockdown mice. Molecular mimics of C3 cleavage products rescue the migration defects that have been seen following knockdown of C3 or Masp2. Pharmacological activation of the downstream receptors rescue Masp2 and C3 knockdown as well as C3 knockout. Therefore, we propose that the complement pathway is functionally important in migrating neurons of the developing cortex.
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