期刊
AAPS PHARMSCITECH
卷 18, 期 6, 页码 2316-2328出版社
SPRINGER
DOI: 10.1208/s12249-017-0711-7
关键词
differential scanning calorimetry; hydration; microemulsion; nail; scanning electron microscopy; terbinafine hydrochloride; transungual drug delivery
资金
- Indian Council of Medical Research (ICMR), New Delhi [45/71/2013/PHA/BMS]
The present study was aimed to optimize, develop, and evaluate microemulsion and microemulsion-based gel as a vehicle for transungual drug delivery of terbinafine hydrochloride for the treatment of onychomycosis. D-optimal mixture experimental design was adopted to optimize the composition of microemulsion having amount of oil (X-1), Smix (mixture of surfactant and cosurfactant; X-2), and water (X-3) as the independent variables. The formulations were assessed for permeation (micrograms per square centimeter per hour; Y-1), particle size (nanometer; Y-2), and solubility of the drug in the formulation (milligrams per milliliter; Y-3). The microemulsion containing 3.05% oil, 24.98% Smix, and 71.96% water was selected as the optimized formulation. The microemulsion-based gel showed better penetration (similar to 5 folds) as well as more retention (similar to 9 fold) in the animal hoof as compared to the commercial cream. The techniques used to screen penetration enhancers (hydration enhancement factor, ATR-FTIR, SEM, and DSC) revealed the synergistic effect of combination of urea and n-acetyl cysteine in disruption of the structure of hoof and hence, leading to enhanced penetration of drug.
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