期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 44, 期 -, 页码 50-58出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2017.02.010
关键词
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资金
- National Science and Engineering Research Council
- Canadian Institutes of Health Research
Narcolepsy is a debilitating sleep disorder caused by loss of orexin neurons in the lateral hypothalamus. Excessive daytime sleepiness and cataplexy are the major complaints in narcolepsy, and are associated with impaired quality of life. Although it is unclear how orexin loss causes sleepiness and cataplexy, animal models have been instrumental in identifying the neurobiological underpinnings of narcolepsy because they reliably recapitulate disease symptoms. Current evidence indicates that orexin cell loss causes sleepiness and cataplexy by destabilizing the ability of the circuits that initiate and sustain normal levels of arousal and. motor activity. This review highlights the latest research concerning the normal function of the orexin system and how its dysfunction causes narcolepsy symptoms.
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