期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 44, 期 -, 页码 89-93出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2017.02.017
关键词
-
资金
- Israel Science Foundation [690/15]
- Legacy Heritage Biomedical Program of the Israel Science Foundation [992/14]
- US-Israel Binational Science Foundation (BSF) [2011335]
- Division Of Physics
- Direct For Mathematical & Physical Scien [2011335] Funding Source: National Science Foundation
What are the molecular and cellular mechanisms that link neurological disorders and sleep disturbances? The transparent zebrafish model could bridge this gap in knowledge due to its unique genetic and imaging toolbox, and amenability to high -throughput screening. Sleep is well characterized in zebrafish and key regulators of the sleep/wake cycle are conserved, including melatonin and hypocretin/orexin (Hcrt), whereas novel sleep regulating proteins are continually being identified, such as Kcnh4a, Neuromedin U, and QRFP. Sleep deficiencies have been observed in various zebrafish models for genetic neuropsychiatric disorders, ranging from psychomotor retardation and autism to anxiety disorders. Understanding the link between neuropsychiatric disorders and sleep phenotypes in zebrafish may ultimately provide a platform for identifying therapeutic targets for clinical trials in humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据