期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 32, 页码 27298-27304出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b07012
关键词
binary nanoparticle-decorated graphene; Au/MNP-decorated graphene; Norovirus-like particle; electrical biosensor; magnetically deposited sensing channel
资金
- Japanese Society for the Promotion of Science (JSPS) [16F16361]
- Grants-in-Aid for Scientific Research [16F16361, 15K04605] Funding Source: KAKEN
Nanoparticle (NP)-decorated carbon nano tubes or graphenes (GRPs) have attracted attention because of their synergic properties such as enhanced electrical conductivity, magneto -optical effect, and plasmon resonance energy transfer. These hybrid carbon nanomaterials are widely used in sensing platforms to monitor target biomolecules, gases, and chemicals. In this study, binary nanoparticles, specifically gold (Au)/magnetic nanoparticle (MNP)-decorated graphenes (GRPs), were applied in a virus-sensing platform. This hybrid material exhibited multiple functionalities, including magnetic, plasmonic, and enhanced electrical properties. The Au/MNP-GRPs were synthesized in two steps at room temperature under mild conditions and magnetically deposited on a Pt-interdigitated electrode as electrical-sensing channels. After deposition onto the electrode, the surface of Au/MNP-GRPs was conjugated with norovirus antibody to produce a norovirus-like particle (NoV-LP)-sensing platform. NoV-LPs were successfully detected by the hybrid nanomaterial-sensing platform, exhibiting high sensitivity and specificity in a concentration range from 0.01 pg to 1 ng. In this case, the limit of detection was calculated as 1.16 pg/mL. Thus, the binary nanoparticle-decorated graphene shows excellent potential as an electrical -sensing platform for biomolecules.
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