期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 163, 期 2, 页码 280-283出版社
SPRINGER
DOI: 10.1007/s10517-017-3784-0
关键词
stress incontinence; vaginal biopsy; Fotona Er: YAG laser; epithelial proliferative activity; immunohistochemistry
The expression of Ki-67 proliferation marker was studied in vaginal biopsy specimens from women with stress urinary incontinence treated using a Fotona nonablative erbium laser. Cells expressing Ki-67 were located in all cases in the parabasal and basal levels of stratified squamous epithelium, the index of labeled nuclei before Er:YAG laser exposure was 19.05 +/- 2.86%. After 1-2 months of laser therapy, the index of labeled nuclei in the epithelium increased significantly and reached 31.79 +/- 2.25%. These changes were interpreted as a result of epithelial-stromal interactions. Presumably, the increase in proliferative activity of the vaginal epithelium after exposure to Er:YAG laser was due to the presence of an appreciable level of synthetically active fibroblasts in the subepithelial stroma.
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