期刊
ADVANCED FUNCTIONAL MATERIALS
卷 27, 期 31, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201700406
关键词
delivery manipulation; endocytosis; ligand-modification anisotropy; nanodiscs; shape anisotropy
类别
资金
- National Key Research and Development Program of China [2016YFA0201400]
- National Natural Science Foundation of China [81690264, 81230036, 81421004]
- National Basic Research Program of China [2015CB932100]
- Innovation Team of the Ministry of Education [BMU20110263]
In an attempt to manipulate the biological features of nanomaterials via both anisotropic shape and ligand modification, four types of nanoparticulates with good morphological stability are designed and engineered, including hybrid nanospheres, nanodiscs, and nanodiscs with edge modification or plane modification of octa-arginine (R8) sequence. It is found that the R8 modification anisotropy can trigger huge differences in the endocytosis, intracellular trafficking, and even tissue penetration of nanoparticulates. From plane modification to edge modification of R8, the maximum increase in cell uptake is up to 17-fold, which is much more significant than shape anisotropy alone. On the other hand, six types of different cell lines are investigated to simulate biological microenvironment. It is demonstrated that the maximum difference in cell uptake among six cell lines is 12-fold. Three main driving forces are found to contribute to such bio-nano interactions. Based on the findings of this study, it seems possible to manipulate the biointeraction mode of nanomaterials and its output by regulating their anisotropy in both shape and ligand modification.
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