期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 490, 期 3, 页码 608-615出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2017.06.085
关键词
Transgenerational effect; Germline apoptosis; Proton beam radiation; Cancer treatment; Caenorhabditis elegans
资金
- NIH Office of Research Infrastructure Programs [P40 OD010440]
- National Research Foundation of Korea (NRF) grant - Korean government (Ministry of Science, ICT and Future Planning) [2015M2B2A4032091]
- National Research Foundation of Korea [2015M2B2A4032091] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
When treating cancer using radiation therapy, it is critical to increase patient survival rates and to reduce side effects. In this respect, proton beam radiation treatment performs better than other radiation treatments because of its high target specificity. However, complications still remain after proton beam radiation treatment. Among them, the risk to progeny after irradiation of their parents is a major concern. In this study, we analyzed the transgenerational effects of proton beam irradiation using the model organism Caenorhabditis. elegans. We found that germline apoptosis increased after proton beam irradiation and its effects were sustained transgenerationally. Moreover, we identified that a germline-specific histone methyltransferase component, SET-2, has a critical role in transmitting the trans generational effect on germline apoptosis to the next generation after proton beam irradiation. (C) 2017 Elsevier Inc. All rights reserved.
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