期刊
NATURE COMMUNICATIONS
卷 8, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-017-01356-z
关键词
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资金
- NIH [R01 NS091010A, R01 EY025349, R01 DC014690, P30 EY022589, U01 NS094342]
- Japan Science and Technology Agency (PRESTO)
- Pew Charitable Trusts, David & Lucile Packard Foundation
- McKnight Foundation
- Human Frontier Science Program
- New York Stem Cell Foundation
- NRSA fellowship [F31NS090858]
Making decisions based on choice-outcome history is a crucial, adaptive ability in life. However, the neural circuit mechanisms underlying history-dependent decision-making are poorly understood. In particular, history-related signals have been found in many brain areas during various decision-making tasks, but the causal involvement of these signals in guiding behavior is unclear. Here we addressed this issue utilizing behavioral modeling, two-photon calcium imaging, and optogenetic inactivation in mice. We report that a subset of neurons in the posterior parietal cortex (PPC) closely reflect the choice-outcome history and historydependent decision biases, and PPC inactivation diminishes the history dependency of choice. Specifically, many PPC neurons show history-and bias-tuning during the inter-trial intervals (ITI), and history dependency of choice is affected by PPC inactivation during ITI and not during trial. These results indicate that PPC is a critical region mediating the subjective use of history in biasing action selection.
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