期刊
BIOLOGICAL PSYCHIATRY
卷 82, 期 4, 页码 275-282出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2015.12.027
关键词
Adversity; Antisocial behavior; Development; Impulsivity; Temporal discounting; Voxel-based morphometry
资金
- European Union [LSHM-CT-2007-037286]
- FP7 project IMAGEMEND
- Innovative Medicine Initiative Project EU-AIMS [115300-2]
- National Institute on Drug Abuse [1R21DA03838]
- National Institutes of Health [1P20GM103644-01A1]
- Medical Research Council Programme Grant [93558]
- Swedish funding agency FORMAS
- Wellcome Trust (University of Cambridge)
- National Institute for Health Research Biomedical Research Centre at South London and Maudsley National Health Service Foundation Trust and King's College London
- Department of Health United Kingdom
- Bundesministerium fur Bildung und Forschung [01GS08152, 01EV0711, SysAlc01ZX1311A]
- Fondation de France
- MRC [G0901858] Funding Source: UKRI
- Medical Research Council [G0901858] Funding Source: researchfish
BACKGROUND: Individual differences in impulsivity and early adversity are known to be strong predictors of adolescent antisocial behavior. However, the neurobiological bases of impulsivity and their relation to antisocial behavior and adversity are poorly understood. METHODS: Impulsivity was estimated with a temporal discounting task. Voxel-based morphometry was used to determine the brain structural correlates of temporal discounting in a large cohort (n = 1830) of 14- to 15-year-old children. Mediation analysis was then used to determine whether the volumes of brain regions associated with temporal discounting mediate the relation between adverse life events (e.g., family conflict, serious accidents) and antisocial behaviors (e.g., precocious sexual activity, bullying, illicit substance use). RESULTS: Greater temporal discounting (more impulsivity) was associated with 1) lower volume in frontomedial cortex and bilateral insula and 2) greater volume in a subcortical region encompassing the ventral striatum, hypothalamus and anterior thalamus. The volume ratio between these cortical and subcortical regions was found to partially mediate the relation between adverse life events and antisocial behavior. CONCLUSIONS: Temporal discounting is related to regions of the brain involved in reward processing and interoception. The results support a developmental imbalance model of impulsivity and are consistent with the idea that negative environmental factors can alter the developing brain in ways that promote antisocial behavior.
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