期刊
ONCOLOGY LETTERS
卷 14, 期 6, 页码 6379-6386出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2017.7033
关键词
microRNA; microRNA-497; tumor growth; insulin receptor substrate 1; colorectal cancer
类别
资金
- National Natural Science Foundation of China [81171653, 30972703, 81201741, 81301960, 81302047]
- Natural Science Foundation of Jiangsu Province [BK2011246, BK2011247, BK20130243]
- Project of Six Batch of Major Talent Summit [BRA2010037]
- Society Development Plans, Department of Science and Technology Changzhou [CJ20112020, CZ20110024, CS20102020]
- Innovative Talents Training Project of Changzhou Health Bureau [2016CZBJ001, 2016CZLJ022]
MicroRNAs (miRNAs) have been demonstrated to serve an important role in diverse biological processes and cancer progression. Downregulation of microRNA-497 (miR-497) has been observed in human colorectal cancer (CRC) tissues, but the function of miR-497 in CRC has not been well investigated. In the present study, it was demonstrated that expression of miR-497 was significantly downregulated in human CRC tissues compared to adjacent normal tissues. Enforced expression of miR-497 inhibited proliferation, migration and invasion abilities of CRC cell lines SW1116 and SW480. Furthermore, overexpression of miR-497 inhibited phosphoinositide 3-kinase/AKT and mitogen-activated protein kinase/extracellular signal-regulated kinase signaling by targeting insulin receptor substrate 1 (IRS1). In human clinical specimens, IRS1 was inversely correlated with miR-497 in CRC tissues. Collectively, the results of the present study demonstrate that miR-497 is a tumor suppressor miRNA and indicate its potential application for the treatment of human CRC in the future.
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