期刊
DEVELOPMENTAL DYNAMICS
卷 246, 期 9, 页码 641-656出版社
WILEY
DOI: 10.1002/DVDY.24530
关键词
heart development; Drosophila cardiogenesis; cardiac mesoderm specification; cardiac morphogenesis; ostia formation; cardiac valve formation; signaling pathways; FGF signaling; Dpp/BMP signaling; Wnt signaling; Notch signaling; Hedgehog signaling; EGFR signaling; Slit-Robo signaling; Integrin mediated signaling; Pvr/VEGF signaling
资金
- American Heart Association [16SDG31390005]
Signal transduction through multiple distinct pathways regulates and orchestrates the numerous biological processes comprising heart development. This review outlines the roles of the FGFR, EGFR, Wnt, BMP, Notch, Hedgehog, Slit/Robo, and other signaling pathways during four sequential phases of Drosophila cardiogenesis-mesoderm migration, cardiac mesoderm establishment, differentiation of the cardiac mesoderm into distinct cardiac cell types, and morphogenesis of the heart and its lumen based on the proper positioning and cell shape changes of these differentiated cardiac cells-and illustrates how these same cardiogenic roles are conserved in vertebrates. Mechanisms bringing about the regulation and combinatorial integration of these diverse signaling pathways in Drosophila are also described. This synopsis of our present state of knowledge of conserved signaling pathways in Drosophila cardiogenesis and the means by which it was acquired should facilitate our understanding of and investigations into related processes in vertebrates. (C) 2017 Wiley Periodicals, Inc.
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