期刊
FEMS MICROBIOLOGY LETTERS
卷 364, 期 13, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femsle/fnx134
关键词
lignin-modifying enzymes (LMEs); white-rot fungi (WRF); cell factory
类别
资金
- BIO-REFinery Integrated Lombardy Labs (BIOREFILL) project [42 611 813]
- FA (Fondo di Ateneo) of the University of Milano-Bicocca
- Sugar BEEt biorefinery for the inTegrated production of biofUel and polyesTers (BEETOUT) project - Fondazione Cariplo (Bando Ricerca Integrata sulle Biotecnologie Industriali e sulla Bioeconomia) [2015-0375]
White-rot fungi are the main natural producers of lignin-modifying enzymes, i.e. laccases and peroxidases, whose secretion and activity allows the depolymerization of lignin and the release of polysaccharides contained in lignocellulose. These enzymes are able to oxidize, in addition to lignin, a wide spectrum of natural and synthetic substrates, making their industrial and biotechnological application appealing. However, the complex regulation of the synthesis of lignin-modifying enzymes, as well as the heterogeneous physiology of fungi in response to nutrients, makes the use of white-rot fungi as production platforms challenging. Finally, yet importantly, analytical methods are not fully standardized, making evaluations and comparisons ambiguous. Consequently, robust and cost-effective fermentative processes for the production of lignin-modifying enzymes by fungi have not yet been fully established, limiting their industrial exploitation. In this review, we describe the importance of both the media composition and the fermentative conditions for leveraging the fungal potential in terms of production titer and enzymatic biodiversity of lignin-modifying enzymes.
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