期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 44, 期 -, 页码 211-218出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2017.05.007
关键词
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资金
- National Institutes of Health [R37 AI36040, RO1 AI080656, R01 AI105101, PO1 AI057788]
- Robert Welch foundation [Q1279]
Recognition and binding to host glycans present on cellular surfaces is an initial and critical step in viral entry. Diverse families of host glycans such as histo-blood group antigens, sialoglycans and glycosaminoglycans are recognized by viruses. Glycan binding determines virus-host specificity, tissue tropism, pathogenesis and potential for interspecies transmission. Viruses including noroviruses, rotaviruses, enteroviruses, influenza, and papillomaviruses have evolved novel strategies to bind specific glycans often in a strain specific manner. Structural studies have been instrumental in elucidating the molecular determinants of these virus-glycan interactions, aiding in developing vaccines and antivirals targeting this key interaction. Our review focuses on these key structural aspects of virus-glycan interactions, particularly highlighting the different strain-specific strategies employed by viruses to bind host glycans.
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