期刊
FEMS MICROBIOLOGY LETTERS
卷 364, 期 12, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femsle/fnx119
关键词
quorum sensing; atypical Pseudomonas aeruginosa strains; LasR deficiency
类别
资金
- Programa de Apoyo a Proyectos de Investigacion e Innovacion Tecnologica (PAPIIT)
- de la Direccion General de Asuntos del Personal Academico (DGAPA)
- Universidad Nacional Autonoma de Mexico (UNAM) [IN200416]
- Consejo Nacional de Ciencia y Tecnologia (CONACYT) [CB-252269]
Pseudomonas aeruginosa is an opportunistic pathogen that presents a complex regulatory network called `quorum-sensing', which is responsible for the transcription of genes coding for several traits implicated in its pathogenicity. Strain 148 is a dolphin isolate that has been shown to produce quorum-sensing-regulated virulence traits and to be virulent in a mouse model, despite the fact that it contains a 20-kbp deletion that eliminates from the chromosome the lasR gene and the lasI promoter. LasR is a key quorum-sensing transcriptional regulator that, when coupled with the autoinducer 3-oxo-dodecanoyl homoserine lactone (3O-C12-HSL) produced by LasI, activates transcription of genes coding for some virulence-associated traits such as elastase, lasI, rhlI and rhlR. RhlR is also a key quorum-sensing transcriptional regulator that, when interacting with the autoinducer butanoyl homoserine lactone (C4-HSL) that is produced by the synthase RhlI, activates the genes involved in the synthesis of some virulence-associated traits, as rhamnolipids and pyocyanin. We describe that in P. aeruginosa 148, the LasR/3O-C12-HSL-independent rhlR transcriptional activation is due to the release of the negative effect of Vfr (a CRP-ortholog) caused by the insertion of an IS element in vfr, and that rhlI transcription is driven from the rhlR promoter, forming the rhlR-I operon.
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