期刊
BRITISH JOURNAL OF CANCER
卷 117, 期 5, 页码 734-743出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2017.231
关键词
height; SNPs; gene and environment interaction; prostate cancer
类别
资金
- European Community's Seventh Framework Programme [223175 (HEALTH-F2-2009-223175)]
- Cancer Research UK [C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565, C5047/A7357, C5047/A3354, C16913/A6135]
- National Institutes of Health [CA128978]
- Post-Cancer GWAS initiative [1U19 CA148537, 1U19 CA148065]
- Department of Defence [W81XWH-10-1-0341]
- Canadian Institutes of Health Research (CIHR)
- CRUK [C18281/A19169]
- Canadian Institutes of Health Research
- National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative [U19 CA 148537-01]
- NIHR
- Royal Marsden NHS Foundation Trust
- Komen Foundation for the Cure
- Breast Cancer Research Foundation
- Ovarian Cancer Research Fund
- Post-Cancer GWAS initiative (GAME-ON initiative) [1U19 CA148112]
- Cancer Research UK [19169, 14835, 13065, 17528, 19170, 15007, 16561] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0513-10121, NF-SI-0510-10096] Funding Source: researchfish
- The Francis Crick Institute
- Cancer Research UK [10124] Funding Source: researchfish
Background: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer. Methods: We analysed data from the PRACTICAL consortium consisting of 6207 prostate cancer cases and 6016 controls and a subset of high grade cases (2480 cases). We explored height, polymorphisms in genes related to growth processes as main effects and their possible interactions. Results: The results suggest that height is associated with high-grade prostate cancer risk. Men with height > 180cm are at a 22% increased risk as compared to men with height < 173cm (OR 1.22, 95% CI 1.01-1.48). Genetic variants in the growth pathway gene showed an association with prostate cancer risk. The aggregate scores of the selected variants identified a significantly increased risk of overall prostate cancer and high-grade prostate cancer by 13% and 15%, respectively, in the highest score group as compared to lowest score group. Conclusions: There was no evidence of gene-environment interaction between height and the selected candidate SNPs. Our findings suggest a role of height in high-grade prostate cancer. The effect of genetic variants in the genes related to growth is seen in all cases and high-grade prostate cancer. There is no interaction between these two exposures.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据