期刊
CHEMIE INGENIEUR TECHNIK
卷 89, 期 8, 页码 995-1005出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cite.201700004
关键词
Blending; Discrete element method; Granular flow; Mixing; Scaling
资金
- Austrian COMET Program
- Austrian Federal Ministry of Transport, Innovation and Technology (BMVIT)
- Austrian Federal Ministry of Science, Research and Economy (BMWFW)
- State of Styria (Styrian Funding Agency SFG)
- Gebruder Lodige Maschinenbau GmbH
Powder mixing is one of the most important pharmaceutical manufacturing operations. Computation methods are required to transform mixer design and scale-up from art to science. Due to an increase in the computational power and the development of graphics cards, the discrete element method is becoming a widely-used technique. For an industrial granular mixer, it is demonstrated that a smart simulation strategy together with a highly efficient code can reduce the simulation time. The good agreement between simulation and measurement data confirms that the simulation strategy can be applied to the product development.
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