期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 33, 页码 27396-27401出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b08824
关键词
graphene quantum dots; cathepsin D-responsive; fluorescence quenching; theranostic
资金
- National Natural Science Foundation of China [21622608, 21373218, 21573234]
- Beijing Talents Fund [2015000021223ZK20]
On the basis of the unique physicochemical properties of graphene quantum dots (GQDs), we developed a novel type of theranostic agent by loading anticancer drug doxorubicin (DOX) to GQD's surface and conjugating Cy5.5 (Cy) dye to GQD though a cathepsin D-responsive (P) peptide. Such type of agents demonstrated superior therapeutic performance both in vitro and in vivo because of the improved tissue penetration and cellular uptake. More importantly, they are capable of functioning as probes for programmed tracking the delivery and release of anticancer drug as well as drug induced cancer cell apoptosis through GQD's, DOX's, and Cy's charateristic fluorescence, respectively.
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