期刊
ARCHIVES OF ORAL BIOLOGY
卷 81, 期 -, 页码 121-130出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.archoralbio.2017.04.029
关键词
Hypoxia; Regeneration; HIF-1; Endodontics; Orthodontics; Periodontics; Oral surgery
资金
- Osteology Foundation (Lucerne, Switzerland) [10-063]
- International Team for Implantology (Basel, Switzerland) [1085_2015]
The understanding of the cell biological processes underlying development and regeneration of oral tissues leads to novel regenerative approaches. Over the past years, knowledge on key roles of the hypoxia-based response has become more profound. Based on these findings, novel regenerative approaches for dentistry are emerging, which target cellular oxygen sensors. These approaches include hypoxia pre-conditioning and pharmacologically simulated hypoxia. The increase in studies on hypoxia and hypoxia-based strategies in regenerative dentistry highlights the growing attention to hypoxia's role in regeneration and its underlying biology, as well as its application in a therapeutic setting. In this narrative review, we present the current knowledge on the role of hypoxia in oral tissues and review the proposed hypoxia-based approaches in different fields of dentistry, including endodontics, orthodontics, periodontics, and oral surgery.
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