期刊
EPIGENOMICS
卷 9, 期 4, 页码 479-492出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2016-0151
关键词
epigenetics; fibroblast-like synoviocytes; histone; methylation; microRNA; rheumatoid arthritis
资金
- Rheumatology Research Foundation
- Arthritis Foundation
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [R01 AR065466]
Rheumatoid arthritis is an immune-mediated disease that primarily affects diarthrodial joints. Susceptibility and severity of this disease are influenced by nongenetic factors, such as environmental stress, suggesting an important role of epigenetic changes. In this review, we summarize the epigenetic changes (DNA methylation, histone modification and miRNA expression) in fibroblast-like synoviocytes, which are the joint-lining mesenchymal cells that play an important role in joint inflammation and damage. We also review the effects of these epigenetic changes on rheumatoid arthritis pathogenesis and discuss their therapeutic potential.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据