期刊
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
卷 17, 期 8, 页码 1046-1069出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1871520617666170213150217
关键词
ROS; cancer; TrxR; anticancer metallodrugs; gold complexes; platinum complexes
资金
- National Natural Science Foundation of China [21302112]
- Natural Science Foundation of Shandong Province [ZR2012HQ002]
Reactive oxygen species (ROS) are produced as normal products of cellular metabolism, which are essential for numerous cell biological functions. Due to aberrant metabolism, oncogenic signaling activation and mitochondrial dysfunction, cancer cells generate excessive ROS that cause severe oxidative damage, finally leading to tumor cell death. Thioredoxin reductase (TrxR), as an important ROS-scavenging enzyme, is overexpressed in various human tumors and plays an important role in regulating intracellular redox homeostasis to protect cancer cells from cell death induced by substantial ROS. Hence, TrxR has emerged as a promising target for anticancer agent development. Currently, metallodrugs with anticancer activity, especially gold- and platinum-complexes, have an enormous impact on clinical cancer chemotherapy. This review provides a comprehensive overview of various metal complexes (gold, platinum, ruthenium, rhodium, iridium, iron, palladium, silver, antimony, bismuth, tin) targeting mammalian TrxR and discusses their cytotoxicity in tumor cells.
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