期刊
ACS MEDICINAL CHEMISTRY LETTERS
卷 8, 期 5, 页码 492-497出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.6b00468
关键词
FMS-like tyrosine kinase 3 (FLT3); acute myeloid leukemia (AML); inhibitor; azo; click-it/staple-it
资金
- Purdue University
- NIH [P30 CA023168]
- China Scholarship Council [201406140119]
Acute myeloid leukemia (AML) is an aggressive malignancy with only a handful of therapeutic options. About 30% of AML patients harbor mutated FLT3 kinase, and thus, this cancer-driver has become a hotly pursued AML target. Herein we report a new class of FLT3 inhibitors, which potently inhibit the proliferation of acute myeloid leukemia (AML) cells at nanomolar concentrations.
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