期刊
MOLECULAR & CELLULAR ONCOLOGY
卷 4, 期 2, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2017.1291397
关键词
Epigenetic reprogramming; mouse models; prostate cancer; therapeutic resistance; tumor suppressor genes
类别
资金
- NCI [R01 CA179907, R01 CA207757]
- Prostate Cancer Foundation Young Investigator Award
- Roswell Park Alliance Foundation
- NCI RPCI Cancer Center Support Grant [P30 CA016056]
Prostate cancer variants expressing alternative lineage markers appear at relapse from antiandrogen therapy. We show that loss of the retinoblastoma (RB1) and tumor protein 53 (TP53) genes drives expression of stem cell reprogramming factors, lineage plasticity, and antiandrogen resistance. Epigenetic manipulation restores antiandrogen sensitivity-suggesting an approach for treating lethal prostate cancers.
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