期刊
CELL
卷 170, 期 5, 页码 927-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2017.07.025
关键词
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资金
- Marsha Rivkin Organization
- Society of Memorial Sloan Kettering, Translational and Integrative Medicine Research Fund (MSKCC)
- Kaleidoscope of Hope
- MSKCC core grant [P30 CA008748]
- Cancer Research UK core grant [C14303/A17197]
- Cancer Research UK Cambridge Institute
- Mexican National Council of Science and Technology (CONACyT)
- Cancer Research UK
- Versus Arthritis [21141] Funding Source: researchfish
We present an exceptional case of a patient with high-grade serous ovarian cancer, treated with multiple chemotherapy regimens, who exhibited regression of some metastatic lesions with concomitant progression of other lesions during a treatment-free period. Using immunogenomic approaches, we found that progressing metastases were characterized by immune cell exclusion, whereas regressing and stable metastases were infiltrated by CD8(+) and CD4(+) T cells and exhibited oligoclonal expansion of specific T cell subsets. We also detected CD8(+) T cell reactivity against predicted neoepitopes after isolation of cells from a blood sample taken almost 3 years after the tumors were resected. These findings suggest that multiple distinct tumor immune microenvironments co-exist within a single individual and may explain in part the heterogeneous fates of metastatic lesions often observed in the clinic post-therapy.
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