期刊
ANNALS OF ONCOLOGY
卷 28, 期 8, 页码 1817-1824出版社
OXFORD UNIV PRESS
DOI: 10.1093/annonc/mdx173
关键词
ARTemis; breast cancer; bevacizumab; neoadjuvant chemotherapy
类别
资金
- Cancer Research UK [CRUK/08/037]
- Roche
- Sanofi
- Cancer Research UK [11010] Funding Source: researchfish
Background: The ARTemis trial previously reported that addition of neoadjuvant bevacizumab (Bev) to docetaxel (D) followed by fluorouracil, epirubicin and cyclophosphamide (D-FEC) in HER2 negative breast cancer improved the pathological complete response (pCR) rate. We present disease-free survival (DFS) and overall survival (OS) with central pathology review. Patients and methods: Patients were randomized to 3 cycles of D followed by 3 cycles of FEC (D-FEC), +/- 4 cycles of Bev (Bev+D-FEC). DFS and OS were analyzed by treatment and by central pathology reviewed pCR and Residual Cancer Burden (RCB) class. Results: A total of 800 patients were randomized [median follow-up 3.5 years (IQR 3.2-4.4)]. DFS and OS were similar across treatment arms [DFS hazard ratio (HR) = 1.18 (95% CI 0.89-1.57), P = 0.25; OS HR = 1.26 (95% CI 0.90-1.76), P = 0.19). Both local pathology report review and central histopathology review confirmed a significant improvement in DFS and OS for patients who achieved a pCR [DFS HR = 0.38 (95% CI 0.23-0.63), P<0.001; OS HR = 0.43 (95% CI 0.24-0.75), P = 0.003]. However, significant heterogeneity was observed (P = 0.02); larger improvements in DFS were obtained with a pCR achieved with D-FEC than a pCR achieved with Bev_D-FEC. As RCB class increased, significantly worse DFS and OS was observed (P for trend<0.0001), which effect was most marked in the ER negative group. Conclusions: The addition of short course neoadjuvant Bev to standard chemotherapy did not demonstrate a DFS or OS benefit. Achieving a pCR with D-FEC is associated with improved DFS and OS but not when pCR is achieved with Bev_D-FEC. At the present time therefore, Bev is not recommended in early breast cancer.
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