期刊
MOLECULAR & CELLULAR ONCOLOGY
卷 4, 期 2, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2016.1277293
关键词
APC/C; antimicrotubule drugs; antimitotic chemotherapy; cullin-RING ubiquitin ligase; cyclin B1; mitotic slippage; tetraploid checkpoint; tetraploidy; ZYG11A; ZYG11B
类别
资金
- National Institutes of Health/National Institute of General Medical Sciences [R01GM074212]
Mitosis inhibitors, which include antimicrotubule drugs, are chemotherapy agents that induce the arrest and apoptosis of mitotic cells. Mitotic slippage, in which mitotically arrested cells exit mitosis, limits the effectiveness of mitosis inhibitors. We have discovered that the CRL2ZYG11A/B ubiquitin ligase promotes mitotic slippage. The combination of antimicrotubule drugs and a CRL2ZYG11A/B inhibitor prevents mitotic slippage to increase antimitotic efficacy.
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