期刊
EXPERIMENTAL AND THERAPEUTIC MEDICINE
卷 13, 期 2, 页码 530-534出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2017.4030
关键词
stromal antigen 2; acute myeloid leukemia; prognosis; mutation; deletion
资金
- Priority Academic Program Development Project of Jiangsu Higher Education Institutions
- Administration of Traditional Chinese Medicine of Jiangsu Province [LZ13207]
- Foundation of Jiangsu Province Health Department [Y201320]
The stromal antigen 2 (STAG2) gene encodes a component of the cohesin complex that participates in the regulation of sister chromatid separation during mitosis. When activated, STAG2 may act as a 'caretaker' tumor suppressor gene. As it is unknown whether STAG2 gene is responsible for the occurrence and associated with the prognosis of acute myeloid leukemia (AML), the present study analyzed the relative expression levels of STAG2 in 127 de novo AML patients and 17 healthy volunteers using reverse transcription-quantitative polymerase chain reaction. In addition, AML patients were divided into three risk groups using cytogenetic and molecular genetic abnormalities to define their risk status. STAG2 gene expression was found to be significantly down regulated in de novo AML patients, when compared with the healthy controls; however, the expression was not significantly different in the various gender and age subgroups. Furthermore, no significant difference between risk groups was detected in AML patients. Thus, the STAG2 gene may serve an important role in AML development, but is not associated with prognosis in AML.
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