期刊
CLINICA CHIMICA ACTA
卷 471, 期 -, 页码 314-320出版社
ELSEVIER
DOI: 10.1016/j.cca.2017.07.001
关键词
Homocysteine; S-adenosylhomocysteine; S-adenosylmethionine; Folate; Coronary artery lesions
资金
- National Natural Science Foundation of China [81373002]
The role of homocysteine (Hcy) in the pathogenesis of coronary artery disease (CAD) is controversial, as decreased Hcy levels have not demonstrated consistent clinical benefits. Recent studies propose that S-adenosylhomocysteine (SAH), and not Hcy, plays a role in cardiovascular disease (CVD). We aimed to assess the relationship between plasma SAH and coronary artery lesions. Participants (n = 160; aged 40-80 years) with chest pain and suspected CAD underwent coronary angiography (CAG) for assessment of coronary artery stenosis, and were assigned to either the atherosclerosis (AS) or CAD group. Plasma SAH and S-adenosylmethionine (SAM) concentrations were measured and the association between coronary artery lesions and. SAH was assessed. SAH levels were significantly higher in the CAD group (23.09 2.4 nmol/L) than in the AS group (19.2 1.5 nmol/L). While the AS group had higher values for SAM/SAH (5.1 0.7 vs. 4.1 1.1), levels of SAM, Hcy, folate, and vitamin B12 were similar in the two groups. Coronary artery lesions were associated with SAH (beta = 11.8 [95% CI: 5.88, 17.7, P < 0.05]. Plasma SAH concentrations are independently associated with coronary artery lesions among patients undergoing coronary angiography. Plasma SAH might be a novel biomarker for the early clinical identification of CVD.
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