期刊
NEOPLASMA
卷 64, 期 4, 页码 526-534出版社
AEPRESS SRO
DOI: 10.4149/neo_2017_406
关键词
miR-361-5p; FOXM1; EMT; lung cancer
类别
资金
- National Natural Science Foundation of China [81372843, 81502518]
Lung cancer is the most common type of cancer and the leading cause of death in worldwide. MicroRNAs are known to be key players in a variety of biological processes, including tumorigenesis. In present study, we investigated the effect of miR-361-5p on lung cancer progression. We found that miR-361-5p was down-regulated in lung cancer. Overexpression of miR-361-5p suppressed lung cancer proliferation and invasion. Mechanistically, FOXM1 was identified as a direct target of miR-361-5p. Furthermore, miR-361-5p inhibits EMT-like phenotype through down-regulation of FOXM1 expression in lung cancer cells. In conclusion, our results indicated that miR-361-5p acts as a tumor suppressor in lung cancer.
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