期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 81, 期 9, 页码 1805-1813出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09168451.2017.1350562
关键词
daidzein; hypocholesterolemic effect; ovariectomy; gene expression; ApoB
类别
资金
- Ministry of Education, Culture, Sports, Science, and Technology, Japan, under a Monbukagakusho scholarship
- Grants-in-Aid for Scientific Research [16K07738] Funding Source: KAKEN
We compared the effects of two major isoflavones, daidzein and genistein, on lipid metabolism in rats. Daidzein (150mg/kg diet), genistein (150mg/kg diet), daidzein and genistein (1:1, 300mg/kg diet), or control diets were fed to 4 groups of 6-week-old ovariectomized (Ovx) and non-Ovx Sprague Dawley rats for 4weeks. Dietary daidzein, but not genistein, reduced serum and hepatic total cholesterol levels significantly relative to that by the control group, regardless of whether the rats had undergone ovariectomy. Genistein did not exhibit any physiological effects on lipid levels, but did affect genes involved in cholesterol metabolism. These results indicate that daidzein and genistein may influence lipid regulation via differing modes of action.
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