期刊
SAUDI PHARMACEUTICAL JOURNAL
卷 25, 期 1, 页码 8-17出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jsps.2015.06.010
关键词
Erythrocytes; Extracellular vesicles; Nanovesicles; Drug delivery
资金
- National Plan for Science, Technology and Innovation
- King Abdulaziz City for Science and Technology, Kingdom of Saudi Arabia [12-MED2563-02]
Nanovesicles (NVs) represent a novel transporter for cell signals to modify functions of target cells. Therefore, NVs play many roles in both physiological and pathological processes. This report highlights biogenesis, composition and biological roles of erythrocytes derived nanovesicles (EDNVs). Furthermore, we address utilization of EDNVs as novel drug delivery cargo as well as therapeutic target. EDNVs are lipid bilayer vesicles rich in phospholipids, proteins, lipid raft, and hemoglobin. In vivo EDNVs biogenesis is triggered by an increase of intracellular calcium levels, ATP depletion and under effect of oxidative stress conditions. However, in vitro production of EDNVs can be achieved via hypotonic treatment and extrusion of erythrocyte. NVs can be used as biomarkers for diagnosis, monitoring of therapy and drug delivery system. Many therapeutic agents are suggested to decrease NVs biogenesis. (C) 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
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