期刊
ENDOCRINOLOGY AND METABOLISM
卷 32, 期 1, 页码 11-17出版社
KOREAN ENDOCRINE SOC
DOI: 10.3803/EnM.2017.32.1.11
关键词
Insulin-like growth factor binding protein 2; Transcriptional regulation; Metabolic diseases; Liver
资金
- Korea New Faculty, Korea Research Foundation, Republic of Korea [NRF-2013R1 A1A1006606]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2015R1D1A1A01057610]
- National Research Foundation of Korea [2015R1D1A1A01057610] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Insulin-like growth factor binding proteins (IGFBPs) are major regulators of insulin-like growth factor bioavailability and activity in metabolic signaling. Seven IGFBP family isoforms have been identified. Recent studies have shown that IGFBPs play a pivotal role in metabolic signaling and disease, including the pathogenesis of obesity, diabetes, and cancer. Although many studies have documented the various roles played by IGFBPs, transcriptional regulation of IGFBPs is not well understood. In this review, we focus on the regulatory mechanisms of IGFBP gene expression, and we summarize the findings of transcription factor activity in the IGFBP promoter region.
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