期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 34, 页码 28185-28194出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b05502
关键词
magnetic DNA microgel; drug release; near-infrared-light responsibility; cancer therapy; Au nanorod
资金
- National Natural Science Foundation of China [21420102006]
- Specialized Research Fund for the Doctoral Program of Higher Education [20130131130005]
Functional DNA molecules have been introduced into polymer based nanocarrier systems to incorporate chemotherapy drugs for cancer therapy. Here is the first report of dual-responsive microgels composed of a core of Au nanorods and a shell of magnetic ionic liquid and DNA moieties in the cross linking network simultaneously, as effective drug delivery vectors. TEM images indicated a magnetic polymer shell has an analogous doughnut shape which loosely surround the AuNRs core. When irradiated with a near-infrared-light (near-IR) laser, Au nanorods are the motors which convert the light to heat, leading to the release of the encapsulated payloads with high controllability. DNA acts not only as a cross-linker agent, but also as a gatekeeper to regulate the release of drugs. The internalization study and MTT assay confirm that these core shell DNA microgels are excellent candidates which can enhance the cytotoxicity of cancer cells controlled by near-IR laser and shield the high toxicity of chemotherapeutic agents to improve the killing efficacy of chemotherapeutic agents efficiently in due course.
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