期刊
BMC NEUROLOGY
卷 17, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12883-017-0945-8
关键词
AIS; Neurogranin; Tau; Plasma; CSF; Elisa; Simoa; NIHSS; mRS; Biomarker
资金
- Agency for Innovation by Science and Technology (VLAIO) [140,105]
- University of Antwerp Research Fund
- Alzheimer Research Foundation (SAO-FRA)
- Institute Born-Bunge (IBB)
- Belgian Science Policy Office Interuniversity Attraction Poles (IAP) program (BELSPO)
- Flemish Government initiated Methusalem excellence grant (EWI)
- Flanders Impulse Program on Networks for Dementia Research (VIND)
- Research Foundation Flanders (FWO)
- VINNOVA
- Swedish Research Council
- Swedish Brain Foundation
- Torsten Soderberg Foundation at the Royal Swedish Academy of Sciences
Background: While neurogranin has no value as plasma biomarker for Alzheimer's disease, it may be a potential blood biomarker for traumatic brain injury. This evokes the question whether there are changes in neurogranin levels in blood in other conditions of brain injury, such as acute ischemic stroke (AIS). Methods: We therefore explored neurogranin in paired cerebrospinal fluid (CSF)/plasma samples of AIS patients (n = 50) from a well-described prospective study. In parallel, we investigated another neuronal protein, i.e. tau, which has already been suggested as potential AIS biomarker in CSF and blood. ELISA as well as Single Molecule Array (Simoa) technology were used for the biochemical analyses. Statistical analyses included Shapiro-Wilk testing, Mann-Whitney analyses and Pearson's correlation analysis. Results: In contrast to tau, of which high levels in both CSF and plasma were related to stroke characteristics like severity and long-term outcome, plasma neurogranin levels were only correlated with infarct volume. Likewise, CSF neurogranin levels were significantly higher in patients with an infarct volume > 5 mL than in patients with smaller infarct volumes. Finally, neurogranin and tau were significantly correlated in CSF, whereas a weaker relationship was observed in plasma. Conclusions: These findings indicate that although plasma and CSF neurogranin may reflect the volume of acute cerebral ischemia, this synaptic protein is less likely to be a potential AIS biomarker. Levels of tau correlated with severity and outcome of stroke in both plasma and CSF, in the present study as well as previous reports, confirming the potential of tau as an AIS biomarker.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据