Enantioselective Hydrogenation of Pyrrolo[1,2-a]pyrazines, Heteroaromatics Containing Two Nitrogen Atoms

An enantioselective iridium-catalyzed direct hydrogenation of heteroaromatics containing two nitrogen atoms, 3-substituted pyrrolo[1,2-a]pyrazines, has been successfully achieved, providing a facile synthesis of optically active 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazines with up to 96% ee.