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POPX2 phosphatase regulates cell polarity and centrosome placement
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Phosphatase Holoenzyme PP1/GADD34 Negatively Regulates TLR Response by Inhibiting TAK1 Serine 412 Phosphorylation
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TAK1 Is Essential for Osteoclast Differentiation and Is an Important Modulator of Cell Death by Apoptosis and Necroptosis
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TAK1 Inhibition Promotes Apoptosis in KRAS-Dependent Colon Cancers
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A Cytosolic ATM/NEMO/RIP1 Complex Recruits TAK1 To Mediate the NF-κB and p38 Mitogen-Activated Protein Kinase (MAPK)/MAPK-Activated Protein 2 Responses to DNA Damage
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Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells
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Investigation of POPX2 phosphatase functions by comparative phosphoproteomic analysis
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CaMKII phosphorylates serine 10 of p27 and confers apoptosis resistance to HeLa cells
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The POPX2 phosphatase regulates cancer cell motility and invasiveness
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ATM- and NEMO-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation in Response to Genotoxic Stress
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A Cytoplasmic ATM-TRAF6-cIAP1 Module Links Nuclear DNA Damage Signaling to Ubiquitin-Mediated NF-κB Activation
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Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop Is Required for Interleukin (IL)-1-mediated Optimal NFκB and AP-1 Activation as Well as IL-6 Gene Expression
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Protein phosphatase 2A is a negative regulator of transforming growth factor-β1-induced TAK1 activation in mesangial cells
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TAK1-binding Protein 1, TAB1, Mediates Osmotic Stress-induced TAK1 Activation but Is Dispensable for TAK1-mediated Cytokine Signaling
Maiko Inagaki et al.
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Functional interactions between phosphatase POPX2 and mDia modulate RhoA pathways
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Activation and regulation of ATM kinase activity in response to DNA double-strand breaks
J-H Lee et al.
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TAB1 modulates IL-1α mediated cytokine secretion but is dispensable for TAK1 activation
Malene Bertelsen et al.
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TAK1-dependent signaling requires functional interaction with TAB2/TAB3
Arnaud Besse et al.
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Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway
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TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis
Emily Omori et al.
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A crosstalk between the Wnt and the adhesion-dependent signaling pathways governs the chemosensitivity of acute myeloid leukemia
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Activation of Akt and ERK signalling pathways induced by etoposide confer chemoresistance in gastric cancer cells
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p21-Activated kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association
SH Jin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Inhibition of CaMKII-mediated c-FLIP expression sensitizes malignant melanoma cells to TRAIL-induced apoptosis
C Xiao et al.
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Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-β-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2
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TAB2 and TAB3 activate the NF-κB pathway through binding to polyubiquitin chains
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Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-κB-dependent XIAP up-regulation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling
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EMBO JOURNAL (2003)
Feedback control of the protein kinase TAK1 by SAPK2a/p38α
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EMBO JOURNAL (2003)
Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cε)
MG Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
CJ Bakkenist et al.
NATURE (2003)
Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol
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The function of multiple IκB:NF-κB complexes in the resistance of cancer cells to Taxol-induced apoptosis
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ONCOGENE (2002)
NF-κB activates Bcl-2 expression in t(14;18) lymphoma cells
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ONCOGENE (2002)
The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family
CG Koh et al.
CURRENT BIOLOGY (2002)
The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca 2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
NF-κB signals induce the expression of c-FLIP
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An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK
K Ono et al.
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Regulation of the TAK1 signaling pathway by protein phosphatase 2C
M Hanada et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1
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A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation
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TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop
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