期刊
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
卷 9, 期 7, 页码 -出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a023887
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资金
- Gates Cambridge Trust
- Becas Chile
- Cambridge Trust
- Biotechnology and Biological Sciences Research Council
- Engineering and Physical Sciences Research Council (OpenPlant) [BB/L014130/1]
- BBSRC [BBS/E/T/000PR5885, BB/L014130/1, BBS/E/T/000PR6193] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/L014130/1, BBS/E/T/000PR5885, BBS/E/T/000PR6193] Funding Source: researchfish
Plants are attractive platforms for synthetic biology and metabolic engineering. Plants' modular and plastic body plans, capacity for photosynthesis, extensive secondary metabolism, and agronomic systems for large-scale production make them ideal targets for genetic reprogramming. However, efforts in this area have been constrained by slow growth, long life cycles, the requirement for specialized facilities, a paucity of efficient tools for genetic manipulation, and the complexity of multicellularity. There is a need for better experimental and theoretical frameworks to understand the way genetic networks, cellular populations, and tissue-wide physical processes interact at different scales. We highlight newapproaches to the DNA-based manipulation of plants and the use of advanced quantitative imaging techniques in simple plant models such as Marchantia polymorpha. These offer the prospects of improved understanding of plant dynamics and new approaches to rational engineering of plant traits.
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