期刊
FRONTIERS IN CARDIOVASCULAR MEDICINE
卷 4, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2017.00052
关键词
integrin alpha2; polymorphism; single nucleotide; thromboembolism; coronary artery disease; clinical study
资金
- German Ministry of Education and Research
- Robert Bosch Stiftung Stuttgart
- Deutsche Forschungsgemeinschaft [B03786/1-1, SCHW858/1-1/2]
- Klinische Forschergruppe [2133-0-0]
Background: Platelet membrane glycoprotein receptors mediate thrombus formation. GP la/Ila is an essential platelet integrin receptor. Single-nucleotide polymorphisms (SNPs) of the GP la/Ila gene alter GP la/Ila expression; however, their influence on cardiovascular disease remains unclear. This study aimed to investigate the effect of the GP la/Ila SNPs rs1126643 and rs1062535 on clinical outcomes in a large collective including high-risk patients with cardiovascular disease. Methods and results: GP la SNP analysis was performed in 943 patients with symptomatic coronary artery disease. All patients were tracked for all-cause death, myocardial infarction, and ischemic stroke for 360 days. Homozygous carriers of the minor allele showed significantly worse event-free survival when compared with major allele carriers in the complete collective as well as in the subset of high-risk patients (carrying all of the following three risk factors: diabetes type II, hypertension, and hyperlipidemia). There was no significant difference in the subset of low-risk patients (carrying none of the three risk factors). Conclusions: GPla SNPs are associated with cardiovascular prognosis especially in high-risk patients. Identification of GPla SNPs is of importance to tailor therapies in patients at already high cardiovascular risk.
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